@AlbertBourlaChairman and CEO of @Pfizer”Success against #COVID19 will likely require both vaccines & treatments. We’re pleased to share we’ve started a Phase 2/3 study of our oral antiviral candidate—specifically designed to combat SARS-CoV-2—in non-hospitalized, low-risk adults…” https://on.pfizer.com/38xBiAF
PRESS RELEASE: First Participant Dosed in Phase 2/3 Study of Oral Antiviral Candidate in Non-Hospitalized Adults with COVID-19 Who Are at Low Risk ofSevere Illness .
New York, N.Y., September 1, 2021 – Pfizer Inc. (NYSE:PFE) today shared that the first participant has been dosed in a pivotal Phase 2/3 clinical trial to evaluate the safety and efficacy of PF-07321332 – an investigational orally administered protease inhibitor antiviral therapy designed specifically to combat COVID-19 – in non-hospitalized, symptomatic adult participants who have a confirmed diagnosis of SARS CoV-2 infection and are not at increased risk of progressing to severe illness, which may lead to hospitalization or death.
Protease inhibitors, like PF-07321332, are designed to block the activity of the main protease enzyme that the coronavirus needs to replicate. Co-administration with a low dose of ritonavir is expected to help slow the metabolism, or breakdown, of PF-07321332 in order for it to remain in the body for longer periods of time at higher concentrations, thereby working continuously to help combat the virus. Ritonavir has previously been used in combination with other antivirals to similarly inhibit metabolism.
This study is part of a global clinical development program, consisting of multiple ongoing and planned clinical trials to evaluate this early-intervention, outpatient therapeutic candidate for potential use in a broad population of patients.
The first registrational trial in this program, a pivotal Phase 2/3 study of PF07321332/ritonavir in non-hospitalized, symptomatic adult participants who have been diagnosed with SARS-CoV-2 infection and are at increased risk of progressing to severe illness, began enrollment in July 2021.
If successful, PF-07321332/ritonavir has the potential to address a significant unmet medical need, providing patients with a novel oral therapy that could be prescribed at the first sign of infection, without requiring hospitalization.
Pfizer is so confident the pill will be approved and likely mandated that it has started production before the end of clinical trials.
Other companies are also hard at work on COVID pills to be taken indefinitely while governments and media corporations focus on COVID.
In Singapore, a 16-year-old boy was ruled to be eligible for a $225,000 settlement this week after suffering a myocarditis cardiac arrest event that doctors ruled was likely in response to receiving his first dose of the Pfizer BionTech vaccine.
Trust the “science”.